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*Correspondence: Kalpana Rajanala [email protected] Upadhyay [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The addition of glucagon receptor agonism raises theoretical considerations around heart rate elevation , and Phase 2 data did show modest increases in resting heart rate in some participants a finding that will require careful monitoring in Phase 3 cardiovascular outcome trials

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